The Signal Peptide of a Recently Integrated Endogenous Sheep 1 Betaretrovirus Envelope Plays a Major Role in Eluding Gag - Mediated Late 2 Restriction 3 4 5
نویسندگان
چکیده
8 MRC University of Glasgow Centre for Virus Research, Institute of Infection, 9 Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, 10 University of Glasgow, United Kingdom 11 EPHE, Université de Lyon 1, INRA, UMR754, École Nationale Vétérinaire de Lyon, 12 IFR 128, Lyon, France 13 Istituto G. Caporale, Teramo, Italy 14 ISPAAM, National Research Council (CNR), Naples, Italy 15
منابع مشابه
The signal peptide of a recently integrated endogenous sheep betaretrovirus envelope plays a major role in eluding gag-mediated late restriction.
The exogenous and pathogenic Jaagsiekte sheep retrovirus (JSRV) coexists with highly related and biologically active endogenous retroviruses (enJSRVs). The endogenous enJS56A1 locus possesses a defective Gag polyprotein which blocks the late replication steps of related exogenous and endogenous retroviruses by a mechanism known as JSRV late restriction (JLR). Conversely, enJSRV-26, which most l...
متن کاملJaagsiekte sheep retrovirus encodes a regulatory factor, Rej, required for synthesis of Gag protein.
Retroviruses express Gag and Pol proteins by translation of unspliced genome-length viral RNA. For some retroviruses, transport of unspliced viral RNA to the cytoplasm is mediated by small regulatory proteins such as human immunodeficiency virus Rev, while other retroviruses contain constitutive transport elements in their RNAs that allow transport without splicing. In this study, we found that...
متن کاملCopy Number Variation and Differential Expression of a Protective Endogenous Retrovirus in Sheep
The Jaagsiekte sheep retrovirus exJSRV and its endogenous counterpart enJSRV co-exist in sheep. exJSRV, a betaretrovirus, is the etiological agent of ovine pulmonary adenocarcinoma, and it has been demonstrated in vitro that an enJSRV Gag variant bearing the R-to-W amino acid change at position 21 was able to block exJSRV budding from the cells, providing a potential protective role for the hos...
متن کاملThe signal peptide of a simple retrovirus envelope functions as a posttranscriptional regulator of viral gene expression.
Retroviruses use different strategies to regulate transcription and translation and exploit the cellular machinery involved in these processes. This study shows that the signal peptide of the envelope glycoprotein (Env) of Jaagsiekte sheep retrovirus (JSRV) plays a major role in posttranscriptional viral gene expression. Expression of the JSRV Env in trans increases viral particle production by...
متن کاملSequences within Both the 5′ UTR and Gag Are Required for Optimal In Vivo Packaging and Propagation of Mouse Mammary Tumor Virus (MMTV) Genomic RNA
BACKGROUND This study mapped regions of genomic RNA (gRNA) important for packaging and propagation of mouse mammary tumor virus (MMTV). MMTV is a type B betaretrovirus which preassembles intracellularly, a phenomenon distinct from retroviruses that assemble the progeny virion at cell surface just before budding such as the type C human and feline immunodeficiency viruses (HIV and FIV). Studies ...
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